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GATE 2026 BT Q.39: solution and answer

GATE 2026 · BTQ.39 · 2 marks · MCQ

Match the biomolecules in Column I with their function given in Column II.

GATE 2026 BT question 39: A two-column table.Tap to open full size
Figure from the GATE 2026 BT paper. It is part of the question.
Figure description

A two-column table. Column I: P. Lectins; Q. P-glycoprotein; R. Digitoxigenin; S. Mannose 6-phosphate. Column II: 1. Acts as ATP dependent pump to efflux out small molecules; 2. Targets lysosomal enzymes to their destination; 3. Specific carbohydrate binding proteins; 4. Inhibits Na+-K+ pump.

  1. (A)

    P-3; Q-2; R-1; S-4

  2. (B)

    P-1; Q-3; R-4; S-2

  3. (C)

    P-2; Q-1; R-3; S-4

  4. (D)

    P-3; Q-1; R-4; S-2

Answer and solution

ANSWER

The correct matching is P-3; Q-1; R-4; S-2, which is option D.

Official answer: DSource: Official answer key, GATE 2026 BT (IIT Guwahati)

  1. P, Lectins: these are proteins that bind specific carbohydrate groups on glycoproteins and glycolipids, so P matches 3.

  2. Q, P-glycoprotein: this is an ABC transporter (MDR1). It uses ATP hydrolysis to pump hydrophobic drugs and other small molecules out of the cell, which gives multidrug resistance. Q matches 1.

  3. R, Digitoxigenin: this is the aglycone of the cardiac glycoside digitoxin. It binds the subunit of the ATPase and inhibits the pump. R matches 4.

  4. S, Mannose 6-phosphate: this is the tag added to N-linked glycans of lysosomal enzymes in the Golgi. The M6P receptor recognises it and sorts the enzymes to lysosomes. S matches 2.

  5. The full matching is P-3; Q-1; R-4; S-2.

  6. Option A is wrong: it gives Q-2 and R-1. Option B is wrong: it gives P-1 and Q-3. Option C is wrong: it gives P-2 and R-3, and P is not the lysosomal targeting signal.

  7. Only option D fits all four pairs.

KEY IDEA

Match each molecule to its role. Lectins bind carbohydrates, P-glycoprotein is an ATP-driven efflux pump, digitoxigenin blocks the Na+-K+ ATPase, and mannose 6-phosphate directs enzymes to lysosomes.

WATCH OUT FOR

Mixing up the lysosomal targeting signal (mannose 6-phosphate) with lectins because both involve sugars. Mannose 6-phosphate is a sorting tag, while lectins are carbohydrate-binding proteins.

From the GATE 2026 BT paper. Every question of this paper · Download the full paper · All 12 Biomolecules questions, with notes

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